OLIGONUCLEOTIDE MICROARRAYS IDENTIFIED POTENTIAL REGULATORY GENES RELATED TO EARLY OUTWARD ARTERIAL REMODELING INDUCED BY TISSUE PLASMINOGEN ACTIVATOR

Oligonucleotide Microarrays Identified Potential Regulatory Genes Related to Early Outward Arterial Remodeling Induced by Tissue Plasminogen Activator

Constrictive vascular remodeling limiting blood flow, as well as compensatory outward remodeling, has been observed in many cardiovascular diseases; however, the underlying mechanisms regulating the remodeling response of the vessels remain unclear.Plasminogen activators (PA) are involved in many of the processes of vascular remodeling.We have show

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Mechanisms involving Ang II and MAPK/ERK1/2 signaling pathways underlie cardiac and renal alterations during chronic undernutrition.

Several studies have correlated protein restriction associated with other nutritional deficiencies with the development of cardiovascular and renal diseases.The driving hypothesis for this study was that Ang II signaling pathways in the heart and kidney are affected by chronic protein, mineral and vitamin restriction.Wistar rats aged 90 days were f

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